foxp3 and tgf-β gene polymorphisms in allergic rhinitis
نویسندگان
چکیده
background: regulatory cd4+t (treg) cells are effective in maintaining immune tolerance. objective: to investigate single nucleotide polymorphisms (snps) of transforming growth factor β-1 (tgf-β1) and forkhead box protein 3 (foxp3) genes in iranian patients with allergic rhinitis (ar). methods: variations at codons 10 and 25 of tgf-β1 and foxp3 at positions -3279 a>c and -924 a>g were evaluated in ar patients and compared with controls. in a case-control study, 155 ar patients and 163 allergy- free controls were genotyped using polymerase chain reaction sequence-specific primer (pcr-ssp) technique. results: the analysis of the frequency of these snps showed that the haplotype formed by foxp3 -3279 a allele occurred significantly more frequently in patients than controls (odds ratio=1.44, 95% ci=1.312-2.66; p=0.001). conclusion: our results suggest that polymorphism in foxp3 gene is associated with susceptibility to ar.
منابع مشابه
FOXP3 and TGF-β Gene Polymorphisms in Allergic Rhinitis
Background: Regulatory CD4+T (Treg) cells are effective in maintaining immune tolerance. Objective: To investigate single nucleotide polymorphisms (SNPs) of Transforming Growth Factor β-1 (TGF-β1) and Forkhead Box Protein 3 (FOXP3) genes in Iranian patients with allergic rhinitis (AR). Methods: Variations at codons 10 and 25 of TGF-β1 and FOXP3 at positions -3279 A>C and -924 A>G were evaluated...
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عنوان ژورنال:
iranian journal of immunologyجلد ۸، شماره ۴، صفحات ۲۱۸-۲۲۵
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